Maryn McKenna

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Much new news on hospital-acquired infections

October 23, 2008 By Maryn Leave a Comment

There’s a ton of new, and conflicting, findings on prevention and detection of hospital-acquired MRSA and other infections.

First: Today, in the journal Infection Control and Hospital Epidemiology, three researchers from Virginia Commonwealth University add to the ferocious debate on “search and destroy,” the colloquial name for active surveillance and testing: that is, checking admitted patients for MRSA, isolating them until you have a result, and and if they are positive, treating them while continuing to isolate them until they are clear. “Search and destroy” has kept in-hospital MRSA rates very low in Europe, and has proven successful in some hospitals in the United States; in addition, four states (Pennsylvania, Illinois, California and New Jersey) have mandated it for some admitted patients at least. Nevertheless, it remains a controversial tactic, with a variety of arguments levelled against it, many of them based on cost-benefit.

Comes now Richard P. Wenzel, M.D., Gonzalo Bearman, M.D., and Michael B. Edmond, M.D., of the VCU School of Medicine, to say that the moment for MRSA search and destroy has already passed, because hospitals are now dealing with so many highly resistant bugs (Acinetobacter, vancomycin-resistant enterococci (VRE), and so on). They contend that hospitals would do better to pour resources into aggressive infection-control programs that broadly target a spectrum of HAIs.

The abstract is here and the cite is: Richard P. Wenzel, MD, MSc; Gonzalo Bearman, MD, MPH; Michael B. Edmond, MD, MPH, MPA. Screening for MRSA: A Flawed Hospital Infection Control Intervention. Infection Control and Hospital Epidemiology 2008 29:11, 1012-1018.

Meanwhile, the US Government Accountability Office recently released a substantive examination of HAI surveillance and response programs, in states and in hospitals, that looks at:

  • the design and implementation of state HAI public reporting systems,
  • the initiatives hospitals have undertaken to reduce MRSA infections, and
  • the experience of certain early-adopting hospitals in overcoming challenges to implement such initiatives. (from the cover letter)

The report is too thick to summarize here, but here are some key points:

  • No two places are doing this the same way — which means that data still does not match state to state
  • Experts are still divided about how much MRSA control is necessary
  • Hospitals that have undertaken MRSA-reduction programs have taken different paths
  • But MRSA control does work: It does reduce in-hospital infections, but at a cost.

This report is an important bookend to an earlier GAO report from last April that explored the poor state of MRSA surveillance nationwide. Read it if you wonder why we don’t really know how much MRSA – in hospitals or in the community – we have.

I am stillworking my way through the new Compendium of Strategies to Prevent Healthcare-Associated Infections in Acute Care Hospitals, released a week ago by a slew of health agencies (Joint Commission, CDC, et al.) and health organizations (American Hospital Association, ACIP, SHEA, IDSA et al.), to see how much the MRSA strategies have actually changed. If anyone has any comments, please weigh in!

Filed Under: CDC, colonization, control, hand hygiene, health policy, HICPAC, infection control, medical errors, nosocomial, surveillance

MRSA in sports

October 21, 2008 By Maryn Leave a Comment

I am possibly the most sports-impaired person on the planet (a consequence of growing up with the lovely but impenetrable game of cricket), but even I noticed these stories recently.

  • University of North Carolina-Asheville basketball center Kenny George has lost part of his right foot to amputation as the result of a staph infection.
  • Cleveland Browns tight end Kellen Winslow has emotionally gone public — to the displeasure of his coaches — with the news that he was hospitalized for three days for a staph infection. Winslow has been struggling with MRSA since 2005, when he had a motorbike accident, had surgery, and developed a post-surgical infection. Four other Browns players — Braylon Edwards, Joe Jurevicius, LeCharles Bentley and Brian Russell — have had MRSA as well.

MRSA in sports is not new news, but the prominence of some of its victims has brought great attention to the bug: For instance, Redskins defensive tackle Brandon Noble, who was sidelined for a season, and eventually ended his career, over a MRSA infection following arthroscopic knee surgery. And it is not limited to pro players: Lycoming College senior Ricky Lanetti died in 2003 from an overwhelming MRSA infection that began as a pimple-like “spider bite” lesion.

There has been so much concern about MRSA among schools and parents that the CDC has issued specific advice for sports programs. Some of the reasons why athletes may be vulnerable are well-understood: They work in crowded conditions, they undergo a lot of skin-to-skin contact, they are likely to get scraped and injured, and they may not get clean immediately (especially high school players — does anyone shower after high school sports any more?).

But some factors, such as the role of artificial turf, are still murky. An investigation of eight MRSA infections among the St. Louis Rams in the 2003 season (first author Sophia Kazakova) found that linemen and linebackers were more likely to develop MRSA, possibly because they ended up with more turf abrasions. On the other hand, an investigation of 10 infections among players at Sacred Heart University in Connecticut (first author Elizabeth Begier) found that, while turf burns played a role, a contaminated team whirlpool — and sharing razors for shaving body hair — did too.

Filed Under: basketball, CDC, community, football, MRSA, schools, sports

Five-fold increase in flu+MRSA deaths in kids

October 7, 2008 By Maryn Leave a Comment

I have a story up this evening at CIDRAP News about a new paper in the journal Pediatrics that analyzes the incidence of child deaths from pneumonia caused by the combination of MRSA and flu, a sad and scary development that we’ve talked about here, here and here.

(NB: CIDRAP News is the original-reporting and news-aggregation arm of the Center for Infectious Disease Research and Policy at the University of Minnesota, an infectious disease research center headed by noted epidemiologist Michael Osterholm, PhD. I have a part-time appointment there. CIDRAP News is the best-read infectious-disease website you have never heard of, with about 10 million visitors a year, and is a notable resource for news on seasonal and pandemic flu, select agents and bioterrorism, and foodborne disease.)

It is bad netiquette and not fair use to reproduce another publication’s entire story here, even if I wrote it. Here though are the highlights:

  • 166 children died of influenza in the past three seasons (2004-05, 2005-06, 2006-07) according to 39 states and 2 local health departments (86 this year in preliminary reporting)
  • The proportion of deaths from bacterial co-infection rose each year, from 6% to 15% to 34%, a five-fold increase
  • Almost all of the bacterial co-infections were staph; 64% of them MRSA
  • The rapid rise in MRSA colonization (from 0.8% of the population in 2001 to 1.5% in 2004 — that’s more than 4 million people) may be playing a role
  • And, some of these deaths could have been avoided if children had had flu shots — but overall, only 21% of under-2s and 16% of 2- to 5-year-olds get the two shots they need to be fully protected against flu.

Please click through to CIDRAP for more.

The cite is: Finelli L, Fiore A, Dhara R, et al. Influenza-associated pediatric mortality in the United States: increase of Staphylococcus aureus coinfection. Pediatrics 2008;122:805-11.

Filed Under: CDC, colonization, influenza, MRSA, pandemic flu, pneumonia, surveillance

CDC educational campaign on antimicrobial resistance

October 2, 2008 By Maryn Leave a Comment

The Centers for Disease Control and Prevention has a long-running educational campaign called “Get Smart: Know When Antibiotics Work.”

But with flu season starting, the agency has decided to make an extra push, hoping to prevent parents from asking pediatricians to prescribe antibiotics for colds and flu. (Which are, all together now: Viruses! And are not affected by: Antibiotics! Gold stars all ’round.) So it has named next week, Oct. 6-10, as “Get Smart About Antibiotics Week.”

There’s a website page specifically for the campaign, which seems to be aimed mostly at health-care institutions and public agencies — places that would mount campaigns and plan activities to reinforce the stewardship message. (The campaign has 14 health-agency and professional-association partners.) If you’re in any of those roles, there are scripts, ads, PSAs, pre-written “articles” and web graphics and widgets. Find them here.

If you’re looking for more general information that you can, for instance, share with friends, this page has explanations in everyday language.

Here’s a question: Are there any readers who are health-care professionals (doctors, nurses, NPs, PAs etc.) who feel you are pressured to prescribe antibiotics? If so, please get in touch via the comments or the email address in the right-hand bio box. I would love to hear from you.

Filed Under: antibiotics, CDC, children, stewardship

Disease-related Do Not Fly list?

September 18, 2008 By Maryn Leave a Comment

This is not strictly MRSA-related, but it is so striking it’s worth posting on. This morning, the Centers for Disease Control and Prevention, the US public health agency, revealed in its weekly bulletin that it has begun maintaining a “Do Not Board” list for people who are thought to be a communicable-disease risk to others.

In slightly more than a year, 33 people have been refused transportation because of the list, which is operated in conjunction with the Department of Homeland Security.

The CDC began operating the list in June 2007, shortly after tuberculosis patient Andrew Speaker flew to Europe and back despite requests by public-health authorities that he not fly; he returned via Canada, driving into the United States to evade an alert given to airlines to locate him. At the time, Speaker was thought to have extensively drug-resistant (XDR) TB, an extremely dangerous form of the disease. Later, his doctors asserted and the CDC agreed that his TB was multi-drug resistant (MDR) — still dangerous, but nowhere near as dangerous as the almost-untreatable XDR form.

Patients’ names can be placed on the list by several entities though all requests are reviewed, the CDC says:

…state or local public health officials contact the CDC Quarantine Station for their region†; health-care providers make requests by contacting their state or local public health departments, and foreign and U.S. government agencies contact the Director’s Emergency Operations Center (DEOC) at CDC in Atlanta.
To include someone on the list, CDC must determine that the person 1) likely is contagious with a communicable disease that would constitute a serious public health threat should the person be permitted to board a flight; 2) is unaware of or likely to be nonadherent with public health recommendations, including treatment; and 3) likely will attempt to board a commercial aircraft.
Once a person is placed on the list, airlines are instructed not to issue a boarding pass to the person for any commercial domestic flight or for any commercial international flight arriving in or departing from the United States. (MMWR 57(37);1009-1012)

An important point here is the phrase “would constitute a serious public health threat.” Under US law (42 USC 264), most public health functions belong to the states, but the federal government is empowered to detain and isolate or quarantine people known or suspected to have a small list of communicable diseases: cholera, diphtheria, infectious tuberculosis, plague, smallpox, yellow fever, viral hemorrhagic fevers (such as Ebola), SARS, and novel strains of flu. The Do Not Board list, however, reaches beyond that list, according to the CDC bulletin:

The public health DNB list is not limited to those communicable diseases for which the federal government can legally impose isolation and quarantine; the list can be used for other communicable diseases that would pose a serious health threat to air travelers. However, to date, the list has only been used for persons with suspected or confirmed pulmonary TB, which is transmitted via the respiratory route and which has had transmission documented during commercial air travel.

Detecting and protecting against disease threats to the US is well within the CDC’s mandate. Still, this raises a huge list of questions, from how medical privacy is maintained when a patient’s name is so widely circulated, to whether healthy people with similar names will be mistaken for sick ones, to how easily people get off the list once they are deemed well.

The CDC says that, of the 33 people placed on the list in the past 15 months, 18 already have been removed. But the persistent problems with the original No-Fly list — snagging air marshals and toddlers and causing passengers to change their names — suggests that this may not be as easy to manage as the CDC thinks. It would be good to hear more about what safeguards they propose — or whether they have left that part of the issue to be handled by DHS.

Filed Under: CDC, health policy, infection control, influenza

New CDC educational campaign on CA-MRSA, aimed at parents

September 8, 2008 By Maryn Leave a Comment

This morning, the CDC is launching a “National MRSA Education Initiative” aimed at raising awareness among parents and average health-care professionals — not academic center researchers so much as front-line nurses, NPs, PAs and others who are likely to be the first set of eyes on a community MRSA infection.

The campaign’s front door is a newly constructed page on the CDC’s website that looks well-stocked with fact sheets for parents and for health-care workers; lots of informative photos, most of them taken by physicians, of what a MRSA skin infection looks like; specific information about MRSA infections in schools and in sports; and a free-of-charge radio PSA.

Especially useful, for those who might need it, is a copy of the CDC’s recommended “treatment algorithm” for suspected MRSA — a flowchart or decision-tree for choosing antibiotics when MRSA is suspected. The algorithm was the result of a number of meetings of experts convened by the CDC and represents the best advice on what to take when. It’s a useful thing to consult if you suspect you may be dealing with MRSA and wonder whether you have been given the appropriate drug. All of these materials are downloadable and printable; open-access/no copyright because they are government-produced.

From the agency’s press release (not posted yetposted here):

The National MRSA Education Initiative is aimed at highlighting specific
actions parents can take to protect themselves and their families. CDC
estimates that Americans visit doctors more than 12 million times per
year for skin infections typical of those caused by staph bacteria. In
some areas of the country, more than half of the skin infections are
MRSA. …
“Well-informed parents are a child’s best defense against MRSA and other
skin infections,” said Dr. Rachel Gorwitz, a pediatrician and medical
epidemiologist with CDC’s Division of Healthcare Quality Promotion.
“Recognizing the signs and receiving treatment in the early stages of a
skin infection reduces the chances of the infection becoming severe or
spreading.”

Filed Under: antibiotics, CDC, children, community, MRSA, praise

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