Resistance: The Movie That Will Make You Care About Antibiotic Misuse

A few years ago I happened to get introduced to a pair of filmmakers, Michael Graziano and Ernie Park, who were starting to explore the topic of antibiotic resistance. They had the same questions about resistance that I obsess over, and the same shock about how enormous the problem is: according to a recent estimate, 700,000 deaths every year, likely to rise into the millions if nothing is done.

They recognized their disbelief as the creative spark for a project, and three years later, have brought out Resistance, a documentary now available on iTunes. LV Anderson just said about it, in Slate:

Regardless of your preexisting interest in public health or food politics, once you learn a little about antibiotic abuse, you won’t be able to stop caring about it. Without antibiotics, many of the medical treatments that we take for granted would be impossible, and the speed and carelessness with which we squander these important drugs — on people who don’t need them and on livestock that really don’t need them — is downright infuriating…  In talking-head interviews with well-chosen, highly articulate experts, Resistance explains the fundamental reason the incorrect use of antibiotics is so dangerous: Every time we use antibiotics, we give bacteria another chance to develop resistance to it.

I think Resistance is a fantastic exploration of the problem, but I am likely to be biased, because I am in it. But I realized as I watched it that there was a lot about the documentary that I didn’t know: how it came to be, why the stories within it were chosen, and whether making it changed the filmmakers’ life.

Here’s an edited chat with Michael Graziano about making the film.

Maryn McKenna: Your previous film, Lunch Line, was about school lunch and nutrition. Antibiotic resistance seems a long way from that. What got you interested?

Michael Graziano: I was hoping to get rich as quickly as possible. I calculated that if I spent three years making a film about science and public health the money would start pouring in.

Turns out my calculations were wrong.

I and my friend Ernie Park, who co-directed Lunch Line, were attending screenings of that film in cities all over the country. Those screenings were often supported by groups that had a concern for child health and welfare, or food more generally. Through working with the former I started to hear about these crazy, antibiotic-resistant MRSA infections that were popping up in school locker rooms and day care centers, and while working with the latter I learned about what many of those groups saw as the overuse of antibiotics in animal agriculture.

Once I began scratching the surface on antibiotics, resistance and the whole constellation of related issues I became interested enough to start working toward a film.

MM: How did you find the people you interviewed, and within those interviews, how did you find your narrative?

Resistance director Michael Graziano and his daughter Tess. courtesy Michael Graziano

Resistance director Michael Graziano and his daughter Tess. courtesy Michael Graziano

MG: Once upon a time I was on track to be a professor somewhere. While that didn’t happen, the seven years I spent in graduate school — first for an MA, then working on a PhD — definitely inform the way I approach subjects: a lot of time reading and taking notes, trying to get my head around it.

For Resistance that meant, starting about three years ago, I read a ton of journal articles by a range of authors, along with books by Stuart Levy, Brad Spellberg, and yours, and others. Research for this project also meant calling and emailing as many people as I could who already understood aspects of the subject much better than I did. I’d become acquainted through Lunch Line, with some smart, generous people from the Pew Charitable Trusts’ antibiotic resistance project, and a few other organizations that have an interest in the way antibiotics are used. They were gracious enough to help with introductions to several experts who appear in the film. Other connections came from mutual acquaintances, while still others came from the experts I’d just met who would say, “Oh, you should really talk to so-and-so. I can introduce you if you’d like.” I’d always say yes.

But the film is not just comprised of experts. I also include the stories and perspectives of individuals who have confronted antibiotic resistance in a personal way, through either their own health or the health of a loved one. I can imagine you’ve experienced this: When individuals or their family members were fighting a serious infection, the last thing a lot of them wanted to do was talk about the process with a stranger with a video camera and microphones. I was lucky in the end to find stories through the same circuitous route of acquaintances and gracious champions.

MM: The film definitely has a framing point of view, in that you don’t interview, for instance, meat industry people, or (many) pharma people. Was this a choice, or were you forced into it by circumstances?

MG: I attempted many times to interview representatives of the meat industry, from the Pork Council, the Animal Health Institute and other organizations. Most simply did not respond to multiple requests. A couple did, and I had nice conversations, but when it came down to scheduling on-camera interviews I couldn’t get anyone to commit. That was in the US. In Denmark I was able to capture representatives from the industry perspective, the regulatory perspective and from the conventional production perspective.

Regarding pharma, I was lucky to meet Dr. John Rex from Astra-Zeneca. He was gracious enough to share his insights with me both as an infectious diseases MD and as an executive at a multinational pharmaceutical company. I did attempt to interview representatives from other pharma companies, and there again had nice conversations with a number of people, but when it came time to actually schedule interviews, once a PR person intervened quash the interview, and other times some set of circumstances made it logistically impossible.

MM: What surprised you most in your reporting?

MG: I had very few preconceptions going into the project. I feel like I’m a relatively well informed person, but before I began research I knew almost nothing about the details and stakes of the antibiotic resistance crisis. So much of what I learned about antibiotics and resistance shocked me: over-prescription in human medicine, the inappropriate use of antibiotics in animal agriculture, the nearly dry global pipeline of new antibiotics, and the ecological implications of these inappropriate uses.

MM: Is there any way in which what you learned caused you to change your own life?

MG: I am much more respectful of and cautious with antibiotics than I was before making the film. Three key changes: I will definitely never demand an antibiotic from a doctor, and if I’m ever in a situation where antibiotics are prescribed for me or one of my children, I will definitely make sure I understand why the doctor is suggesting that course of action. I will never use “antibacterial products” that contain triclosan and other chemical antibacterials. I no longer buy meat that was raised with antibiotics.

MM: So… are we doomed?

MG: I think we’re locked in a race between our ability to adapt to new circumstances and information, and the inertia of our habits, entrenched ways of thinking, and institutions. Whether we’ll be able to adapt to what we know about antibiotics and what we’re learning about our place within the microbial ecology of the planet remains to be seen. But the intelligent, dedicated individuals that I met during the production of the film and since, who relentlessly work to improve our public and personal health, and to help us make smarter decisions, give me hope for the future.


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