Maryn McKenna

Journalist and Author

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Resistance: The Movie That Will Make You Care About Antibiotic Misuse

February 24, 2015 By Maryn Leave a Comment

A few years ago I happened to get introduced to a pair of filmmakers, Michael Graziano and Ernie Park, who were starting to explore the topic of antibiotic resistance. They had the same questions about resistance that I obsess over, and the same shock about how enormous the problem is: according to a recent estimate, 700,000 deaths every year, likely to rise into the millions if nothing is done.

They recognized their disbelief as the creative spark for a project, and three years later, have brought out Resistance, a documentary now available on iTunes. LV Anderson just said about it, in Slate:

Regardless of your preexisting interest in public health or food politics, once you learn a little about antibiotic abuse, you won’t be able to stop caring about it. Without antibiotics, many of the medical treatments that we take for granted would be impossible, and the speed and carelessness with which we squander these important drugs — on people who don’t need them and on livestock that really don’t need them — is downright infuriating…  In talking-head interviews with well-chosen, highly articulate experts, Resistance explains the fundamental reason the incorrect use of antibiotics is so dangerous: Every time we use antibiotics, we give bacteria another chance to develop resistance to it.

I think Resistance is a fantastic exploration of the problem, but I am likely to be biased, because I am in it. But I realized as I watched it that there was a lot about the documentary that I didn’t know: how it came to be, why the stories within it were chosen, and whether making it changed the filmmakers’ life.

Here’s an edited chat with Michael Graziano about making the film.

Maryn McKenna: Your previous film, Lunch Line, was about school lunch and nutrition. Antibiotic resistance seems a long way from that. What got you interested?

Michael Graziano: I was hoping to get rich as quickly as possible. I calculated that if I spent three years making a film about science and public health the money would start pouring in.

Turns out my calculations were wrong.

[Read more…]

Filed Under: Science, Science Blogs, Superbug Tagged With: agriculture, antibiotics, documentary, Resistance

White House Actions on Antibiotic Resistance: Big Steps, Plus Disappointments

September 22, 2014 By Maryn Leave a Comment

Roman Boed (CC), Flickr

Roman Boed (CC), Flickr

The United States government proposed several important steps last week that, if accomplished, will significantly change how this country attempts to counter the advance of antibiotic resistance, bringing us within reach of the more complete programs which exist in Europe. But as significant as it is, the new program has some perplexing gaps that left experts attending to the issue disappointed.

[Read more…]

Filed Under: Science, Science Blogs, Superbug Tagged With: agriculture, animals, antibiotics, Resistance, White House

What the Forthcoming White House Report on Antibiotic Resistance Will Ask For

July 11, 2014 By Maryn Leave a Comment

e-Magine Art (CC), Flickr

e-Magine Art (CC), Flickr

Among the groups that work on awareness of antibiotics resistance — which include major medical and public health organizations as well as nonprofits trying to direct attention to antibiotic misuse in medicine and agriculture — there has been a lot of anticipation of a forthcoming report by the President’s Council of Advisors on Science and Technology. The report, which has been in the works for months, will be published shortly, possibly as early as next week. Today, the council — known as PCAST for short — held a public meeting to discuss the report’s contents and vote as a group to accept or rejected. The meeting was webcast, and as far as I could tell, the vote was unanimous.

Though the report itself won’t be out for a bit, the meeting gave a good sense of what the report will say. For accessibility, PCAST runs live voice-recognition transcription of its meetings; so while the meeting was proceeding, I grabbed a transcript to review later. Here’s what seems to be coming.

[Read more…]

Filed Under: Science, Science Blogs, Superbug Tagged With: agriculture, antibiotics, FDA, Resistance

Denmark: Three Deaths from Drug-Resistant "Pig MRSA"

May 12, 2014 By Maryn Leave a Comment

ICStefanescu (CC), Flickr

Image: ICStefanescu (CC), Flickr

A troubling and also kind of odd story came out of Denmark this weekend. In a court proceeding, a microbiologist has disclosed that three residents of the country who had no known connection to farming died of MRSA infections caused by ST398, the livestock-associated strain of drug-resistant staph that first appeared among pig farmers in the Netherlands in 2004 and has since moved through Europe, Canada and the United States.

If the report is correct — and sources have told me it is, but I’ve seen no data to confirm it — it reinforces the concern that bacteria which become resistant because of antibiotic use on farms can move off farms and affect the health of people who have no connection to farming.

Livestock MRSA has always one of the best cases for establishing that, because the drug to which it showed the greatest resistance, tetracycline, wasn’t used against human MRSA in the Netherlands, but was used routinely on farms — so the only place the strain could have picked up its unique resistance pattern was in pigs. (Here’s my long archive of posts on pig MRSA, dating back to my book Superbug where the story was told for the first time.)
[Read more…]

Filed Under: Science, Science Blogs, Superbug Tagged With: agriculture, antibiotics, Denmark, food policy, food safety, MRSA, netherlands, Resistance, ST398

Antibiotic Overuse on Farms: Is the Opinion Tide Turning?

November 4, 2013 By Maryn Leave a Comment

USDA Photos by Lance Cheung/Flickr

It’s been a busy few weeks here at Casa Superbug — including some conference appearances, more on them later — so the first thing I’d like to do is point out some things that appeared while I was offline. Notably: In editorials, three newspapers recently challenged the way antibiotics are used on farms and asked why we can’t do better.

[Read more…]

Filed Under: Science, Science Blogs, Superbug Tagged With: agriculture, animals, antibiotics, food policy, food safety, Science Blogs

Shutdown Salmonella Outbreak Continues. CDC Food Safety Chief: 'We Have a Blind Spot.'

October 10, 2013 By Maryn Leave a Comment

Image: Ben Husmann, (CC), Flickr

We’re 11 days now into the federal shutdown and four days since the announcement of a major foodborne outbreak in chicken that is challenging the shutdown-limited abilities of the food-safety and disease-detective personnel at the Centers for Disease Control and Prevention, Food and Drug Administration and Department of Agriculture. Here’s an update.
[Read more…]

Filed Under: Science, Science Blogs, Superbug Tagged With: agriculture, antibiotics, CDC, FDA, food policy, food safety, Resistance, salmonella, Science Blogs, Shutdown

CDC Threat Report: Yes, Agricultural Antibiotics Play a Role in Drug Resistance

September 17, 2013 By Maryn Leave a Comment

Campylobacter bacteria. Image: CDC

The grave assessment on the advance of drug resistance, released Monday by the US Centers for Disease Control and Prevention, contained some important observations about the relationship between antibiotic use in agriculture and resistant infections in humans. Those observations, combined with remarks made yesterday by the director of the CDC and also with testimony given in the past by other CDC personnel, ought to put to rest what seems like a persistent meme: that the CDC has never said, or doesn’t believe, that agricultural antibiotic use plays a role in the advance of resistance.

This is important because it puts the CDC in line with a substantial body of research pointing to agricultural use playing a role in the emergence of resistance outside farm properties. With the CDC agreeing — plus, to some degree, the Food and Drug Administration — surely it’s time to move on to whether there are things that could be done to curb the risks posed by some ag practices, while respecting the role that livestock-raising in particular plays as a substantial economic sector, and as an engine in feeding the world.

[Read more…]

Filed Under: Science, Science Blogs, Superbug Tagged With: agriculture, animals, antibiotics, CDC, E. coli, FDA, Resistance, salmonella, Science Blogs

Two Former FDA Commissioners Agree: Ag Antibiotic Policies Must Change

August 27, 2013 By Maryn Leave a Comment

source: Anselm (CC), Flickr

This is an ICYMI (“in case you missed it”) post, twice over. Last week, former Food and Drug Administration Commissioner Donald Kennedy, Ph.D., wrote a piece for the Washington Post in which he urged that the FDA change how it regulates antibiotics that are used in agriculture as part of meat production.

His prescription is notable, not just in itself, but because it marks the second time in a few months that a former commissioner of the FDA used a major paper’s op-ed page to criticize his former agency’s conduct on farm antibiotic use. David A. Kessler, M.D., did the same thing, hitting many of the same points, in the New York Times in March.

Kennedy was FDA Commissioner from 1977 to 1979, just as scrutiny of antibiotic use in livestock-raising was beginning. (There’s a timeline in this post.) Kessler was Commissioner from 1990 to 1997, during the time in which the FDA began to look for, and find, antibiotic-resistant bacteria on retail meat. There were almost 20 years between their tenures — and 16 years from Kessler to now — and yet almost nothing has changed.

[Read more…]

Filed Under: Science, Science Blogs, Superbug Tagged With: agriculture, animals, antibiotics, FDA, food, food policy, food safety, growth promoters, Resistance, Science Blogs

More on MRSA on Farms and in Farm Workers, and the Arguments for and Against

July 12, 2013 By Maryn Leave a Comment

Photo: ROIrving/ Flickr

In my last post I promised to catch up on some of the other research that has been published on the flow of MRSA (and other resistant organisms) between farm animals and farm workers as a result of farm antibiotic use.

Before I do that, though, I want to nod toward two other great pieces published on this. First, Mark Bittman  examined this issue closely at the New York Times. And Clare Leschin-Hoar also covered the new research at Take Part. (Bonus: Don’t miss her dissection of the news that a National Geographic photographer was arrested in Kansas after taking pictures of a feedlot — from the air.)

[Read more…]

Filed Under: Science, Science Blogs, Superbug Tagged With: agriculture, animals, antibiotics, food, food policy, food safety, hogs, MRSA, Science Blogs, ST398

"Pig MRSA" Carried by Workers from North Carolina Intensive Hog Farms

July 5, 2013 By Maryn Leave a Comment

Pig farms from the air. Maryn McKenna, Creative Commons License

I saved this post until today to allow everyone to get their holiday hot dogs guilt-free. Now that’s over: An important study has just been published which makes a close connection between the emergence of antibiotic-resistant bacteria, and the use of antibiotics on large-scale conventional hog farms. Bonus: It involves the resistant bacterium MRSA ST398 (known in shorthand as “pig MRSA”), which is widespread in Europe but up to this point has been found mainly in only one state in the US, Iowa. With this paper, the count rises to two(see Update): The study subjects in this paper are hog-farm workers in eastern North Carolina.

A quick explanation of why this is important: “Pig MRSA” is a particular strain of drug-resistant staph that is slightly different from the hospital and community (sports, gym) varieties. It was first spotted in the Netherlands in 2004, in the toddler daughter of pig farmers and in the family’s pigs. Since then, it has spread widely across Europe, not just in agriculture, but in healthcare and in everyday life, and has also been found widely in retail meat.

The question of whether livestock production’s use of antibiotics causes antibiotic-resistant bacteria to move into the wider world is much argued-over, and pig MRSA, or ST398 to be polite, is crucial to that dispute. That’s because, unlike most resistant bacteria, it has a genetic signature that makes an inarguable link back to farm drug use. More on that below. (If you want more, here’s an archive of my posts on ST398; the story of its emergence in 2004 and what happened afterward is told in my 2010 book SUPERBUG.)

Now, the study. Quick summary, with more unpacking to follow: Researchers checked livestock-farm workers in North Carolina to see whether they were carrying staph, and also drug-resistant staph. The workers formed two groups: one group worked at conventional hog operations, which routinely use antibiotics, and the other group at antibiotic-free farms. Both groups carried staph and also drug-resistant staph, which would be expected; about 30 percent of the population carries sensitive staph and about 4 percent carries the drug-resistant form. But, the key difference: Workers from the conventional, antibiotic-using farms were many times more likely to carry staph with the specific signature of farm-drug use.

That illuminates a potential occupational risk to the workers — and it also suggests that the workers could be a channel for that farm-influenced bacterium to move off the farm.

[Read more…]

Filed Under: Science, Science Blogs, Superbug Tagged With: agriculture, animals, antibiotics, food, food policy, food safety, hogs, MRSA, North Carolina, Science Blogs, ST398

G8 Meeting Begins: Ag Antibiotics on Agenda?

June 17, 2013 By Maryn Leave a Comment

Photo: Caro’s Lines (CC), Flickr

Quick post today as I’m getting ready for some travel. Just to note: The G8 summit is beginning in Ireland, and there is a push on to put intensive agriculture and its antibiotic use on the agenda for discussion by the major Western economies.

[Read more…]

Filed Under: Science, Science Blogs, Superbug Tagged With: agriculture, animals, antibiotics, food, food policy, Science Blogs

The Cool Factor (With Feathers): New York Chefs React To Pastured Poultry

June 11, 2013 By Maryn Leave a Comment

Photo: OZinOH/Flickr

If you’ve been around here a while, you might remember a couple of posts about the pastured-poultry movement. Pastured poultry is new old-style: beyond cage-free, beyond free-range, it puts chickens out on grass for most of their lives, producing a bird that lives longer, looks healthier, and tastes distinctly different from standard supermarket chicken. (“They have huge, old-fashioned taste,” Shaun Doty, a chef who has been working with them, told me last year. “They cook differently, and they eat differently.”

Pastured poultry represents a radically different way of raising chicken than the standard large-intensive model: no antibiotic use, no crammed chicken houses, no genetic-monoculture birds with their inevitable physical vulnerabilities. So far, it’s a niche in the market: The number of producers is small, the birds are more expensive — and even though the chickens taste like what our grandparents would have eaten, most of us have never known chicken tasted like that, so they can be a challenge to sell. The first problem, though, is raising awareness that the alternative exists at all.

[Read more…]

Filed Under: Science, Science Blogs, Superbug Tagged With: agriculture, animals, antibiotics, chicken, poultry, Science Blogs

How Do You Know Which Chicken to Buy? This Kickstarter Might Help.

May 31, 2013 By Maryn Leave a Comment

 

There’s a project I’ve been watching on Kickstarter and I’m a little surprised it hasn’t gotten more traction, so I thought I’d call it out. TL;DR: You know those wallet cards and apps that help you make good choices about buying seafood: what’s endangered, what’s overfished, what’s responsible to eat? This effort, BuyingPoultry.com, hopes to do the same for chicken — but it’s only halfway to its goal.

[Read more…]

Filed Under: Science, Science Blogs, Superbug Tagged With: agriculture, animals, antibiotics, chicken, Kickstarter, NARMS, poultry, Resistance, Science Blogs

Industrial Slaughter, Antibiotic Use and Unhealthy Meat: Ted Conover in Harper's

April 29, 2013 By Maryn Leave a Comment

I don’t often recommend print magazines here, because I figure they already have their own megaphone, and whatever power we at Wired have to push along other writers, I’d rather use to promote bloggers who might not have high traffic. That said: There is a piece in the current Harper’s which should be a must-read for anyone interested in livestock agriculture and meat production in America, written by long-time immersive journalist and NYU professor Ted Conover. It is entirely behind a paywall, and so (to my perception) is not being talked about — but it should be. It is a detailed and unbiased account of how large-scale slaughter happens, and it makes some important points about routine antibiotic use.

[Read more…]

Filed Under: Science, Science Blogs, Superbug Tagged With: agriculture, animals, antibiotics, food, food policy, meat, Science Blogs

Gene Sequencing Pinpoints Antibiotic Resistance Moving From Livestock to Humans

March 28, 2013 By Maryn Leave a Comment

The antibiotic era was barely 20 years old when people started raising concerns about using the new “miracle drugs” in agriculture. Penicillin first entered use in 1943, streptomycin in 1944, tetracycline in 1948 — and by 1965, the United Kingdom’s Agricultural Research Council was hearing testimony that organisms common in food animals, especially Salmonella, were becoming resistant to the antibiotics being used on the animals while they were alive. By 1969, the UK government had compiled an official report outlining the danger, and by 1973, a task force of the US Food and Drug Administration had concurred, and concluded the only safe action was to withdraw approval to use antibiotics in animals. (At which, as we now know, they would never be successful.)

The policy difficulty regarding this long-recognized problem has never been the emergence of resistant bacteria on farms; no one seriously disputes that resistance emerges whenever antibiotics exert selective pressure on bacteria, killing the vulnerable and opening an ecological niche into which the surviving not-vulnerable can expand. The  sticking point has been the difficulty of proving that those resistant bacteria depart from farms, cross to humans, and cause resistant illness in them. Stuart Levy demonstrated it in 1976, on an experimental farm plot he set up just to make the proof. Most of the rest of the research, though — and after decades, there are hundreds of pieces of research — has been observational and retrospective: Looking at the drugs administered to populations of animals (about which we have very little data), measuring the antibiotic-resistant illness that arises in the human population, and making increasingly sophisticated backward matches between the resistance factors that show up in humans and the drugs that are deployed primarily on farms.

Demonstrating the bacterial traffic prospectively and experimentally, as Levy did, is challenging not just logistically but also ethically. It is difficult to imagine a study design that could trace specific animals, their meat, and their eaters in a large group of free-living humans; and unless you have volunteers, as Levy did, the study would push ethical boundaries as well. But having that lack of definition in the middle of the animal-to-human bacterial flow permits uncertainty — which proponents of continued ag antibiotic use exploit.

A new study of Danish farmers and their livestock may have ended that uncertainty. It is still retrospective, but its observations — using whole-genome sequencing — are so fine-grained that their tracing of the bacterial traffic seems to me to be difficult to challenge.

[Read more…]

Filed Under: Science, Science Blogs, Superbug Tagged With: agriculture, animals, antibiotics, food, food policy, MRSA, Resistance, Science Blogs, ST398

Antibiotic-Resistant Bacteria Surround Big Swine Farms — In China as Well as the U.S.

February 12, 2013 By Maryn Leave a Comment

I suspect we think of large-scale confinement agriculture as a uniquely American issue. Possibly that’s because growth-promoter antibiotic use, which makes meat-raising efficient, originated in the United States; more likely, it’s because some of the largest firms in that sector — Smithfield and Tyson, for example — are US-based. But public and private research efforts (including the US Department of Agriculture, the United Nations’ Food and Agriculture Organization and the Pew Charitable Trusts) have documented that intensive livestock-raising is increasing in emerging economies such as India and China; as incomes rise, demand for meat does too.

A paper published Monday in the Proceedings of the National Academy of Sciences demonstrates that the unintended consequences of confinement agriculture are occurring in those countries as well. A multi-national team of researchers from Michigan State University and two campuses of the Chinese Academy of Sciences found — well, I can’t put it better than their paper’s title does: “Diverse and abundant antibiotic resistance genes in Chinese swine farms.”

[Read more…]

Filed Under: Science, Science Blogs, Superbug Tagged With: agriculture, animals, antibiotics, China, food, food policy, food safety, pigs, Resistance, Science Blogs

Antibiotics and Antibiotic-Resistant Bacteria in Meat: Not Getting Better

February 9, 2013 By Maryn Leave a Comment

A few days ago, the Food and Drug Administration released two important documents related to antibiotic use in livestock raising, and what the results of that antibiotic use are. I’d say that they released them quietly, except, when it comes to this issue, every release seems to be quiet, never accompanied by the press releases or briefings that other divisions of the FDA use to publicize their news.

The two documents are the 2011 Retail Meat Report from the National Antimicrobial Resistance Monitoring System, or NARMS, and the 2011 Summary Report on Antimicrobials Sold or Distributed for Use in Food-Producing Animals, which is known for short as ADUFA, after the 2008 Animal Drug User Fee Act that mandated the data be collected.

These two reports capture almost all the data we receive from the federal government about antibiotic use in livestock production (which is not the same thing as “all the data the federal government possesses” — there is evidence they receive more than they release). So their annual release is an important indicator for whether antibiotic use in meat production, and antibiotic resistance in meat, are trending up or down.

The news does not appear to be good.

[Read more…]

Filed Under: Science, Science Blogs, Superbug Tagged With: agriculture, animals, antibiotics, FDA, food, food policy, food safety, NARMS, Resistance, Science Blogs

Why We Can't See Inside Poultry Production, and What Might Change if We Could

January 29, 2013 By Maryn Leave a Comment

 

In the past months, there have been several troubling research reports, from different parts of the world, exploring aspects of the same problem: Multi-drug resistant bacteria are present in chicken, apparently because of the use of antibiotics in poultry production, and are passing to people who work with, prepare or eat chicken, at some risk to their health.

Here are a few of the publications:

  • From the US Department of Agriculture and University of Georgia, which has probably the deepest poultry-science research bench in the United States, an analysis of multi-drug resistant E. coli found on broiler chicken carcasses.
  • From several institutions in Germany, an analysis that finds “alarmingly high” levels of multi-drug resistant bacteria on retail chicken — including on organic chicken, which the authors say may be due to bacterial colonization of chicks before they are bought by organic producers.
  • From the Czech Republic, a report that bacteria found on chicken there are resistant to an additional class of drugs important in human medicine, fluoroquinolones.
  • From a multi-national team, a look at the close resemblance of multi-drug resistant E. coli between poultry and humans in several countries including the United States.
  • And most recently, two more European reports, from the Netherlands and from Sweden, of high rates of multi-drug resistant bacteria on chicken meat (and in the Netherlands paper, a comparison to resistant bacteria in humans as well).

[Read more…]

Filed Under: Science, Science Blogs, Superbug Tagged With: agriculture, antibiotics, chicken, food, food policy, food safety, foodborne, poultry, Resistance, Science Blogs

2012 In The Rear-View Mirror: What You Liked

January 1, 2013 By Maryn Leave a Comment


Happy New Year, constant readers. For the second year in a row, here’s my list of which of my posts (91 in 2012!) most moved you to react. Last year (find that list here), I counted down based on which posts provoked the most comments. This year, Wired installed a tweet-counter — which registers only if someone clicks through from Twitter, but not if the post’s URL is mentioned or RT’d — so I thought it would be amusing to score posts that way this year.

And the verdict is: You care enormously about food policy, but you continue to be fascinated by the emergence of scary diseases — and, to my surprise and pleasure, you care about public understanding of science as well.

[Read more…]

Filed Under: Science, Science Blogs, Superbug Tagged With: agriculture, antibiotics, chagas, chicken, diabetes, FDA, NRDC, poultry, Resistance, Science Blogs, shrimp, TB

The Lost History and Unintended Consequences of the Chicken Nugget

December 28, 2012 By Maryn Leave a Comment

A close look at the interior of a McDonald’s McNugget. Bought, sliced open, shot by me. CC 3.0 attrib-noncomm.

There are things in your life that are so ubiquitous, you never stop to consider them. Traffic signals. Magnets. For me, chicken nuggets. They seem to be everywhere: every fast-food chain, every kids’ menu, every supermarket freezer aisle. I don’t particularly care for them, but I never stopped to wonder where they came from. I assumed, as with so much else in our food culture,  McDonald’s was responsible, and other food producers had followed the McNugget’s market-devouring lead.

Well, yes, and no. As part of my reporting on food policy, I’ve been looking into the history of poultry production — and reading up on what drove its vast post-war expansion, I stumbled across the lost history of the nugget. It appears to have been invented — or at least, originally proposed — by a Cornell professor, 17 years before McDonald’s had essentially the same idea.

[Read more…]

Filed Under: Science, Science Blogs, Superbug Tagged With: agriculture, chicken, poultry, Science Blogs

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