Maryn McKenna

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New Analysis Says FDA Farm Antibiotic Reduction Won't Work As Planned

December 3, 2014 By Maryn Leave a Comment

Epsos.de (CC) on Flickr

Epsos.de (CC) on Flickr

A brand-new analysis of the Food and Drug Administration’s plans to restrict agricultural overuse of antibiotics brings some needed clarity to the subject — and calls into question how effective those plans will be.

The analysis, published by the Pew Charitable Trusts, examines whether the FDA’s request to veterinary pharma companies — to observe voluntary curbs on the antibiotics they sell — is actually going to make much difference in quantities of antibiotics that are used. And concludes: Maybe not.

[Read more…]

Filed Under: Science, Science Blogs, Superbug Tagged With: antibiotics, FDA, growth promoters

How Agriculture's Growth Promoters Might Work: A Mouse Study Sheds Some Light

August 19, 2014 By Maryn Leave a Comment

Rama (CC), FLickr

Rama (CC), Flickr

The farm practice that underlies most agricultural use of antibiotics is known as “growth promotion”: It calls for giving very small doses of antibiotics routinely to meat animals because those doses cause them to gain fat and muscle more quickly than they would otherwise. Growth promotion dates back to the early days of the antibiotic era, and has always been somewhat mysterious. Though there were attempts to pick apart its mechanisms in the 1950s and 1960s (I’ve been reading some fascinating old accounts), for the most part, people simply accepted that it worked. It’s only in the past decade or so, as interest has increased in the microbes that reside everywhere in our and animals’ bodies (a vast community generally known as the microbiome), that researchers have begun trying to dissect what is going on.

The scientific team that has probably pursued this most intensely is the NYU Langone Medical Center lab led by Martin J. Blaser. Blaser published a popular account of their research into antibiotics’ effect on obesity, asthma, diabetes, and other disorders in Missing Microbes: How the Overuse of Antibiotics Is Fueling Our Modern Plagues, published in April. (Disclosure: I reviewed the book for Nature.) Two years ago, the team showed that giving small doses of antibiotics to very young mice affected genes controlling metabolism of nutrients, and caused the mice to gain weight. Now they have followed up that research with detailed work exploring how much the timing and length of antibiotics affects weight gain. Though the work is still in mice, it leads to provocative conclusions about how growth promoters work in livestock, and what early-life antibiotics might do to humans as well.

[Read more…]

Filed Under: Science, Science Blogs, Superbug Tagged With: antibiotics, growth promoters, microbiome, Resistance

Report: FDA Documents Show Decade of Unsuccessful Attempts to Control Farm Antibiotics

January 28, 2014 By Maryn Leave a Comment

Image: gina pina/Flickr

Image: gina pina/Flickr

A nonprofit group that has been using the courts to pressure the Food and Drug Administration into exerting more control over farm antibiotic overuse has done a deep review of FDA documents prised loose through Freedom of Information Act requests — and concludes that by allowing the drugs to remain on the market as formulated, the agency isn’t meeting its own internal safety standards.

Instead of only making that assertion, the Natural Resources Defense Council took the unusual step of showing its evidence in detail. NRDC published its analysis, Playing Chicken with Antibiotics, alongside a selection of the raw documents it received from the FDA. You’ll have to be a document-obsessive to take it on: The file (cached in a Dropbox and requiring download to view) is 306 mb and 971 pages. But even without considering its content, the file’s heft makes clear how much discussion there has been at the FDA over this issue, and suggests how much evidence has been accumulating over the problem of antibiotic resistance emerging from livestock production. Also telling: The FDA has been attempting to put some controls on livestock production since 1977; these documents cover only reviews of antibiotic feed additives that were conducted between 2001 and 2010.

NRDC’s conclusion, in its report:

FDA’s scientific reviewers’ findings show that none of these products would likely be approvable as new additives for nontherapeutic livestock use if submitted today, under current FDA guidelines. Eighteen of the 30 reviewed feed additives were deemed to pose a “high risk” of exposing humans to antibiotic-resistant bacteria through the food supply, based on the information available. The remainder lacked adequate data for the reviewers to make any determination and their safety remains unproven. In addition, FDA concluded in their review that at least 26 of the reviewed feed additives do not satisfy even the safety standards set by FDA in 1973.

[Read more…]

Filed Under: Science, Science Blogs, Superbug Tagged With: animals, antibiotics, FDA, food policy, food safety, growth promoters, NRDC, Resistance, Science Blogs

Re-Examining the FDA Antibiotics Decision: Banning Growth Promoters Won't Be Enough

December 27, 2013 By Maryn Leave a Comment

USDA Photos by Lance Cheung/Flickr

In my first take on the news of the FDA finalizing its request to agriculture to stop using growth-promoter antibiotics, I promised to come back for a more thoughtful reaction. And then this happened, and this happened, and the holidays happened, and, well, it’s been a busy few weeks.

So, finally getting back to it: When the news broke, a number of people, including me, said that this was a long-awaited first step on the part of the FDA, but of uncertain ultimate impact because it asks for voluntary action and does not address whether the drugs simply can be relabeled. I still agree with both those points, but think the possibly most important issue — which I raised briefly in the first post  — is that merely removing antibiotics, without changing the system in which those antibiotics have been administered, may cause significant animal-welfare problems, without having any real effect on human health.

(If you’d like the short version of this, listen to my chat with NPR’s Weekend All Things Considered.)

[Read more…]

Filed Under: Science, Science Blogs, Superbug Tagged With: animals, antibiotics, FDA, food, food policy, food safety, growth promoters, Resistance, Science Blogs

FDA Finally Imposes Some Controls on Agricultural Antibiotics. Sort Of.

December 11, 2013 By Maryn Leave a Comment

USDA Photos by Lance Cheung/Flickr

This morning, the US Food and Drug Administration dropped some long-awaited-but-still-big news regarding the use of antibiotics in meat production. Tl;dr: The FDA asked (but did not compel) the livestock industry to stop using the micro-dose “growth promoter” antibiotics that are widely believed to contribute to increase in antibiotic resistant bacteria in animals, food and humans.

With exquisite timing, they happen to have picked a day when I am traveling, in order to get to my end-of-semester evaluation tomorrow for my  MIT fellowship. So I’m going to do what curation I can on this, and point to some important reactions and analyses. I’ll come back for a deeper look, probably on the weekend.

So here are the basics.

[Read more…]

Filed Under: Science, Science Blogs, Superbug Tagged With: animals, antibiotics, FDA, food policy, food safety, growth promoters, Resistance, Science Blogs

Two Former FDA Commissioners Agree: Ag Antibiotic Policies Must Change

August 27, 2013 By Maryn Leave a Comment

source: Anselm (CC), Flickr

This is an ICYMI (“in case you missed it”) post, twice over. Last week, former Food and Drug Administration Commissioner Donald Kennedy, Ph.D., wrote a piece for the Washington Post in which he urged that the FDA change how it regulates antibiotics that are used in agriculture as part of meat production.

His prescription is notable, not just in itself, but because it marks the second time in a few months that a former commissioner of the FDA used a major paper’s op-ed page to criticize his former agency’s conduct on farm antibiotic use. David A. Kessler, M.D., did the same thing, hitting many of the same points, in the New York Times in March.

Kennedy was FDA Commissioner from 1977 to 1979, just as scrutiny of antibiotic use in livestock-raising was beginning. (There’s a timeline in this post.) Kessler was Commissioner from 1990 to 1997, during the time in which the FDA began to look for, and find, antibiotic-resistant bacteria on retail meat. There were almost 20 years between their tenures — and 16 years from Kessler to now — and yet almost nothing has changed.

[Read more…]

Filed Under: Science, Science Blogs, Superbug Tagged With: agriculture, animals, antibiotics, FDA, food, food policy, food safety, growth promoters, Resistance, Science Blogs

A Government Takes Ag Antibiotics Seriously — But Not Our Government

January 15, 2013 By Maryn Leave a Comment

Matt Rourke/AP

It’s always fascinating to me to see how seriously other parts of the world take the issue of antibiotic use in agriculture, given the long struggle in the United States to get the Food and Drug Administration to act and to get legislation through Congress. The European Parliament has voted down any prophylactic antibiotic use, and China has banned growth promoters.

And last week, the UK Parliament examined the issue for the first time in more than a decade, in a long debate that featured some stinging language by members of Parliament and, it must be said, some inadequate responses by a government agency.

[Read more…]

Filed Under: Science, Science Blogs, Superbug Tagged With: animals, antibiotics, EU, food, food policy, growth promoters, Resistance, Science Blogs, UK

People Want to Eat Meat Raised Without Excessive Antibiotics. Wouldn't You?

June 20, 2012 By Maryn Leave a Comment

This news is going to be everywhere today, but it’s solidly in the topics I care about (and you readers care about — at least I think you do), so I’m going to cover it regardless.

The magazine Consumer Reports is publishing a report and poll on US consumers’ attitudes toward the overuse of antibiotics in agriculture. From everyone’s reactions when I write about this, I thought people cared about this issue, but the numbers are a little surprising even to me: 86 percent of shoppers in a nationally representative sample of 1,000 adults said they wanted meat raised without antibiotics to be available in their local supermarkets. [Read more…]

Filed Under: Science, Science Blogs, Superbug Tagged With: agriculture, animals, antibiotics, FDA, food, food policy, food safety, growth promoters, Resistance, Science Blogs, USDA

Court Scolds FDA Over Ag Antibiotic Use

June 5, 2012 By Maryn Leave a Comment

There’s been another development in the continuing court battle to get the US Food and Drug Administration to exert some control over agricultural use of growth-promoter antibiotics — and it arrives accompanied by some remarkably direct language from the US magistrate judge hearing the case.

In a Memorandum of Opinion and Order that was filed last Friday afternoon — which I extracted from the PACER system and stashed in my Scribd account — Judge Theodore Katz addresses the FDA’s denial of two citizens’ petitions regarding ag antibiotic use. I’ll explain the details below, but here is the key language:

… the Court finds the Agency’s denial of the Petitions to be arbitrary and capricious. For over thirty years, the Agency has been confronted with evidence of the human health risks associated with the widespread sub-therapeutic use of antibiotics in food-producing animals, and, despite a statutory mandate to ensure the safety of animal drugs, the Agency has done shockingly little to address these risks.

Whew. OK, the details:

[Read more…]

Filed Under: Science, Science Blogs, Superbug Tagged With: animals, antibiotics, FDA, food, food policy, growth promoters, NRDC, Resistance, Science Blogs

Antibiotics in Ethanol Grains: Glass Half-Empty or Half-Full?

April 10, 2012 By Maryn Leave a Comment

So hi. Apologies to disappear, constant readers — I was mired in the last revise of a big magazine story (which will be out in two months and will be very exciting). Back now, and catching up. Here’s something that caught my eye yesterday, on a topic that I haven’t looked at since this blog was at its former home: the issue of ethanol-manufacturing leftovers, and whether they contribute to antibiotic resistance in the animals they are fed to.

Quick background: Making ethanol is a lot like brewing beer. You take a starchy carbohydrate, wet it down to make a mash, warm it up, add yeast, and wait. To fuel its reproduction, the yeast digests the carbohydrate; as waste products, it respires carbon dioxide and produces alcohol. (So basically beer is yeast pee, but let’s not get off track.)

[Read more…]

Filed Under: Science, Science Blogs, Superbug Tagged With: animals, antibiotics, Ethanol, food, food policy, growth promoters, Science Blogs

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