antibiotics Archives - Page 4 of 9 - Maryn McKenna

The 'NIH Superbug': A New Case, And An Overlooked Resource

September 17, 2012 By Maryn Leave a Comment

News, via the Washington Post‘s hard-working health reporter Brian Vastag: After 6 months with no cases, carbapenem-resistant Klebsiella has surfaced again at the Clinical Center of the National Institutes of Health, and has killed a boy from Minnesota who came to the specialty hospital after a bone-marrow transplant meant to address an immune deficiency. This sad event makes the boy the 19th patient to contract the extremely resistant hospital organism, and the 12th to die from it, since the outbreak began.

You can find here my last post analyzing this outbreak (which was originally reported by the Post following a write-up by NIH staff in the journal Science Translational Medicine). I’m looping back to the subject not just because of this new death, but also to add a few new publications to the discussion, one of them mine.

Drug Resistance in Food: Chicken, Shrimp, Even Lettuce (ICAAC 4)

September 13, 2012 By Maryn Leave a Comment

A final post from the ICAAC meeting, which concluded at one end of the Moscone Center in San Francisco Wednesday just as the Apple iPhone 5 launch was beginning at the building’s other end. (Definitely a crossing of geek streams.)

There’s far too much going on at a meeting like this to cover everything. So what emerges, as journalists move around the session rooms and exhibit floors, are stories regarding whatever caught a reporter’s eye based on his or her existing interests and news sense.

What caught my eye was a lot of research into foodborne illness, and particularly into the possibility of food being a reservoir for antibiotic resistance (which, constant readers will know, is something I’m interested in). [Read more…]

E. Coli Behaving Badly: Hospitals, Travel, Food (ICAAC 2)

September 11, 2012 By Maryn Leave a Comment

A quicker post today from the ICAAC meeting because there’s lots of news coming down this afternoon. At a conference like this, where the focus is on new behavior of pathogens and new drug compounds to contain them, there is a natural focus on emerging antibiotic resistance. Out of the first two days of (hundreds of) papers and posters, here are just a few unnerving reports.

News Round-Up: Sausage, Soil, Skeeters, Camping, China, Chimps And Other Hazards

August 31, 2012 By Maryn Leave a Comment

This has been my week: Oh, wow: I should write about that. No, wait — that. Damn, new news; I’ll blog this paper instead. Except, hold on — this one is great too…

So to solve my indecision before the week ends, here you go: Most of this week’s most interesting news, in round-up form.

Superbug Summer Books: Experiment Eleven

August 26, 2012 By Maryn Leave a Comment

In the history of antibiotics, the creation myth is the discovery of penicillin. In 1928, Alexander Fleming leaves a window open in his laboratory, a breeze blows across his culture plates, and when he returns to retrieve the plates for cleaning, he discovers that tiny specks of mold that have landed on the plates have killed the staph he had been culturing. The mold is Penicillium, and the compound it produces, once refined and reproduced in a laboratory, launches what we think of as the antibiotic era, and changes medicine forever.

But while penicillin jumpstarts antibiotic production, it is another antibiotic — streptomycin — which arguably creates the pharmaceutical industry, by being the first antibiotic to be patented. (The original penicillin never was, due to complications of timing, and also to its developers’ conviction that it belonged to the world.)

The story of the discovery of streptomycin is much less well-known than that of penicillin. But it ought to be much better-known — because as longtime journalist Peter Pringle recounts in a new book, “Experiment Eleven: Dark Secrets Behind the Discovery of a Wonder Drug” (Walker), it contains so much that is so relevant today, not just to the process of drug discovery, but to the conduct of research. If you care about fairness or justice, Pringle’s account of how graduate student Albert Schatz, the actual identifier of the drug, was deprived of recognition — and a fortune in royalties — will enrage you. If you are a junior scientist, I suspect it will give you nightmares.

The 'NIH Superbug': This Is Happening Every Day

August 24, 2012 By Maryn Leave a Comment

I mentioned in my last post that I’ve been away on assignment and have been trying to catch up to an onslaught of news. One of the things that broke while I was gone was a new paper in Science Translational Medicine describing the ferocious impact on a hospital at the National Institutes of Health of the arrival of carbapenem-resistant Klebsiella pneumoniae, known for short as KPC or CRKP.

Even though the news is now several days old — the paper went live at noon Wednesday and has been covered in most major media since — I think it’s worth doubling back to take a closer look. Because, with all respect to my media colleagues, I think some of this week’s stories have omitted the larger context. So, a different kind of post for me — less news, more analysis, based on this book, this magazine story, and these past posts on antibiotic resistance. Here we go:

Resistant Gonorrhea: CDC Says Just One Drug Left

August 9, 2012 By Maryn Leave a Comment

Well, that didn’t take long.

Exactly 6 months after warning, in a major medical journal, that gonorrhea was becoming untreatable by the last two drugs commonly used against it, the Centers for Disease Control has taken one of those drugs off the table, leaving just one antibiotic available to treat the disease.

In a bulletin published today, the public health agency says that data from the national Gonococcal Isolate Surveillance Project shows a high enough percentage of resistance to the oral cephalosporin cefixime that “CDC no longer recommends cefixime at any dose as a first-line regimen for treatment of gonococcal infections.” Instead, it says, physicians should administer a single dose of injectable ceftriaxone, accompanied by some additional oral drugs.

This has been coming for a while, but it is still unnerving news. It means that the entire structure of sexually transmitted disease control in the United States — single doses of drugs given in single outpatient-clinic visits — now hangs on this one remaining drug. If ceftriaxone also becomes ineffective, then STD treatment will instead become a matter of giving drugs by IV: slower, more complicated, more expensive, and likely more difficult to access.

Drug-Resistant Gonorrhea: Not Just A U.S. Problem

August 3, 2012 By Maryn Leave a Comment

If you’ve been reading along, you might remember that in the past year, there has been increasing alarm in the public health community about rising rates of drug-resistant gonorrhea, an almost-beaten sexually transmitted disease that has steadily become resistant to just about all the drugs that can be used against it in the outpatient clinics on which STD control relies. (If you haven’t been reading along, then first, Welcome, and second, here are one two three four posts about the problem.)

Highly resistant gonorrhea — which is to say, gonorrhea that has already become resistant to sulfa drugs, penicillin, tetracycline, and fluoroquinolones such as Cipro, and that is gaining resistance to cephalosporins — first emerged in Japan and over the past decade was carried to the western United States, and then crossed the country. But a recent issue of EuroSurveillance, the journal of the European Centre for Disease Prevention and Control, warns that cases are now increasing in Europe, and exhibiting resistance against the last drug that both worked and was uncomplicated to use.

Investigation: Drug Resistance, Chicken And 8 Million UTIs

July 11, 2012 By Maryn Leave a Comment

So, there’s this thing. A big project. An investigative project, actually. I’ve been working on it for months, and finally I can tell you about it, because it all just published, in various venues, today.

I’ve been working with a great new group, the Food and Environment Reporting Network — one of the grant-funded journalism organizations that have arisen in the wake of the collapse of mainstream journalism — on an important, under-reported topic. Which is: Over the past decade, a group of researchers in several countries have been uncovering links between the use of antibiotics in chicken production and the rising occurrence of resistance in one of the most common bacterial infections in the world.

People Want to Eat Meat Raised Without Excessive Antibiotics. Wouldn't You?

June 20, 2012 By Maryn Leave a Comment

This news is going to be everywhere today, but it’s solidly in the topics I care about (and you readers care about — at least I think you do), so I’m going to cover it regardless.

The magazine Consumer Reports is publishing a report and poll on US consumers’ attitudes toward the overuse of antibiotics in agriculture. From everyone’s reactions when I write about this, I thought people cared about this issue, but the numbers are a little surprising even to me: 86 percent of shoppers in a nationally representative sample of 1,000 adults said they wanted meat raised without antibiotics to be available in their local supermarkets. [Read more…]

Beyond Factory Farming: Creating An Appetite For Pastured Poultry

June 11, 2012 By Maryn Leave a Comment

I get this a lot: “I understand that the things you write about are important — but they’re so depressing. Couldn’t you write some, you know, good news, for a change?”

So here you go: a solutions post for once, instead of another problem. (But I can’t promise to make a habit of it.)

The Superbugs In Your Dinner: A Storify

June 7, 2012 By Maryn Leave a Comment

As I said Wednesday would happen, I participated in a Twitterchat today about antibiotic-resistant foodborne illnesses arising as a result of agricultural antibiotic use. This is the subject of my investigative piece in the June issue of SELF Magazine. Chat participants were me and blogger and cancer survivor Lisa Bonchek Adams, with many constant readers checking in. And because I’m sure you were all busy, but I want you to know what we talked about, I made a Storify for you. You’re welcome.

Drug-Resistant Gonorrhea: WHO Agrees It's An Emergency

June 6, 2012 By Maryn Leave a Comment

Image: KaptainKobold/Flickr

The World Health Organization has weighed in on the growing threat from antibiotic-resistant gonorrhea, saying in a statement this morning (emailed, and apparently not online):

Millions of people with gonorrhoea may be at risk of running out of treatment options unless urgent action is taken, according to the World Health Organization (WHO). Already several countries, including Australia, France, Japan, Norway, Sweden and the United Kingdom are reporting cases of resistance to cephalosporin antibiotics — the last treatment option against gonorrhoea. Every year an estimated 106 million people are infected.

The statement arrived as an adjunct to the launch of the WHO’s new global action plan for controlling the spread of resistant gonorrhea.

If you’ve been reading here for a while, the problem of resistant gonorrhea won’t be new to you. (Here are some past posts on data from the CDC and a call to action in the New England Journal of Medicine, along with a piece I wrote in Scientific American and a separate post by my SciAm editor Christine Gorman.) But in case you’ve just come in:

The Superbugs in Your Dinner (Bonus: Twitterchat!)

June 6, 2012 By Maryn Leave a Comment

I have a new story up at SELF Magazine, where I’m privileged to do a long and often investigative piece about once a year. This one is close to my heart: It took two years to complete, and in that time I conducted 37 interviews and reviewed several hundred scientific papers.

Here’s what it says: The misuse of antibiotics in agriculture, particularly in livestock-raising, is creating antibiotic-resistant foodborne illnesses that are taking victims and their doctors by surprise.

We talk pretty often here about drug-resistant bacteria arising as a result of farm antibiotic use, and moving off the farm in a variety of ways. There is a lot of dispute, of course, about whether farm-caused antibiotic resistance has much effect on human health, or whether the various resistant illnesses that people contract arise instead from antibiotic misuse in daily life or in hospitals and health care.

But in this case, the illnesses are being caused specifically by classic foodborne bugs that have become resistant and are making people sick when the food is handled or eaten. The evidence is not 100 percent — no evidence ever is — but to me, these illnesses demonstrate the most direct link yet between antibiotic use on farms, and human illness far away from farm areas.

Court Scolds FDA Over Ag Antibiotic Use

June 5, 2012 By Maryn Leave a Comment

There’s been another development in the continuing court battle to get the US Food and Drug Administration to exert some control over agricultural use of growth-promoter antibiotics — and it arrives accompanied by some remarkably direct language from the US magistrate judge hearing the case.

In a Memorandum of Opinion and Order that was filed last Friday afternoon — which I extracted from the PACER system and stashed in my Scribd account — Judge Theodore Katz addresses the FDA’s denial of two citizens’ petitions regarding ag antibiotic use. I’ll explain the details below, but here is the key language:

… the Court finds the Agency’s denial of the Petitions to be arbitrary and capricious. For over thirty years, the Agency has been confronted with evidence of the human health risks associated with the widespread sub-therapeutic use of antibiotics in food-producing animals, and, despite a statutory mandate to ensure the safety of animal drugs, the Agency has done shockingly little to address these risks.

Whew. OK, the details:

What Industrial Farming Has to Do With Devastated Seas

May 24, 2012 By Maryn Leave a Comment

I spent the end of last week at the latest iteration of the Sustainable Foods Institute, an intense two days of discussion that the Monterey Bay Aquarium (home of Seafood Watch, the guide to sustainable seafood choices) puts on every year to bring together journalists, advocates and chefs. The Institute takes place within Cooking for Solutions, an overlapping food and wine conference dedicated to the proposition that sustainability and care for the planet are inseparable from deliciousness.

This is not as universal an idea as you might think. As the conference was opening, the New York Times ran a joint interview with the globally influential chefs Thomas Keller and Andoni Luis Aduriz in which they explicitly rejected ecological concerns over where or from whom they source the food they serve. Keller: “Is global food policy truly our responsibility? … I don’t think so.” Aduriz: “To align yourself entirely with … sustainability makes chefs complacent and limited.” (In a great response piece, Grist food editor Twilight Greenaway explains why their thinking is so short-sighted.)

But “global food policy” ought to be the concern of anyone who raises, grows, catches, fishes, forages, sells or even just eats food — because, as University of Minnesota academic Jonathan Foley said in a devastating talk halfway through the two days: “We’re running out of everything. We’re running out of planet.”

We're Using More of the Few Antibiotics Left

May 16, 2012 By Maryn Leave a Comment

When medicine runs out of effective antibiotics, what does it do?

It turns to the uneffective ones. And patient care suffers.

People on the front lines of antibiotic resistance — infectious-disease physicians and nurses, and the patients sick or unlucky enough to contract a resistant infection — have been insisting for a while that this is happening. Their alarm has not been much-noticed. A paper published this evening might change that. (Link fixed from earlier.)

Mothers, Farmers and Chefs Against Antibiotic Misuse

May 15, 2012 By Maryn Leave a Comment

If you’ve been reading me for a while, you may remember Everly Macario and her son Simon Sparrow: I told their story in my 2010 book Superbug and blogged about them in 2011. Everly is a public health researcher in Chicago and the sister and daughter of physicians. Yet despite all her own knowledge, and all the knowledge resident in her family, she was unable to protect 17-month-old Simon from the MRSA infection that killed him in 24 hours in 2004.

Simon, as I wrote about him last year, was:

[A] big, sturdy child with no health problems except a touch of asthma. The day before he died, he woke up feverish and disoriented, startling his parents with a cry unlike anything they had heard from him before. It was a busy morning — his older sister had a stomach virus — but they got him to the pediatric ER, got him checked, and brought him home when doctors found nothing unusual going on.

A few hours later, Everly was working at home, watching both kids, and Simon’s breathing changed. Her husband James, a history professor, had driven a few hours away to give a speech. She called a friend who is a pediatrician, held the phone up to Simon’s nose and mouth so she could hear, and then got back on the line.

“Hang up,” her friend said. “Call 911.”

She did, and then she called her husband, who reversed course and began tearing back to the city. At the hospital, Simon failed rapidly: His heart raced, his blood pressure crashed, his lungs filled with fluid. His skin darkened with pinpoint hemorrhages. He died the following morning.

Simon Sparrow. Photo: Courtesy Everly Macario

Drug-Resistant Gonorrhea: How We Lost Track

May 4, 2012 By Maryn Leave a Comment

if I were starting this blog today, I’d be tempted to name it the Department of Unintended Consequences. So much of what I write about seems to belong in that zone: Send U.N. troops to Haiti, start a cholera epidemic. Aim to eradicate wild polio, clear the way for the vaccine-derived kind. Drive down the price of producing animal protein, ramp up antibiotic resistance.

Now add to the list: Develop cheap rapid tests for detecting sexually transmitted diseases, and lose the ability to track that those diseases are becoming resistant to the last antibiotics that work reliably against them.

Antibiotics in Ethanol Grains: Glass Half-Empty or Half-Full?

April 10, 2012 By Maryn Leave a Comment

So hi. Apologies to disappear, constant readers — I was mired in the last revise of a big magazine story (which will be out in two months and will be very exciting). Back now, and catching up. Here’s something that caught my eye yesterday, on a topic that I haven’t looked at since this blog was at its former home: the issue of ethanol-manufacturing leftovers, and whether they contribute to antibiotic resistance in the animals they are fed to.

Quick background: Making ethanol is a lot like brewing beer. You take a starchy carbohydrate, wet it down to make a mash, warm it up, add yeast, and wait. To fuel its reproduction, the yeast digests the carbohydrate; as waste products, it respires carbon dioxide and produces alcohol. (So basically beer is yeast pee, but let’s not get off track.)